Houston Methodist study reveals COVID-19 UK variant cases doubling weekly in Houston

Genome sequencing results show UK strain more contagious and highlight importance of vaccination

Newswise — Houston Methodist infectious disease pathologists have discovered new COVID-19 cases caused by the SARS-CoV-2 UK B.1.1.7 variant are doubling weekly. By mid-March the number increased sharply to 648 cases from 305 just a week earlier. The findings come from the latest batch of 8,857 virus genomes sequenced from patients with positive COVID-19 tests in the first two months of 2021, representing 94% of Houston Methodist cases.

“We’ve estimated the doubling time for UK variant B.1.1.7 to be approximately seven days, which has Houston on track to be dominated by this variant within the next four to six weeks,” said James M. Musser, M.D., Ph.D., chair of the Department of Pathology and Genomic Medicine at Houston Methodist. “This work clearly shows a very rapid spread of the UK B.1.1.7 variant in the metropolitan Houston area.”

Dr. Musser said his team is sequencing additional SARS-CoV-2 genomes daily, so numbers of the UK variant will increase as a consequence.

“Like in Houston, there is something preferential for this variant in the U.K., which currently accounts for 98% of new cases in that country,” Musser said. “Given that similarity and the doubling rate we estimated for Houston, it’s crucial for individuals to get vaccinated as soon as possible to control the spread of this very contagious and increasingly common variant. In the meantime, I can’t stress enough the importance of continuing the fundamental precautions of wearing masks, social distancing and limiting exposure to large gatherings.”

He cautions that present figures will always be a lagging number, underestimating the true presence of this variant. Two other virus variants from South Africa and Brazil, however, have not increased at all. There is something preferential to the UK B.1.1.7 variant that is conducive to it spreading throughout the Houston metropolitan area.

Given the immediate community and national impact of these findings, a report was posted on the preprint server medRxiv. The manuscript, titled “Rapid, widespread, and preferential increase of SARS-CoV-2 B.1.1.7 variant in Houston, TX, revealed by 8,857 genome sequences,” is also under peer-review with a prominent medical journal. Musser is the corresponding author on the study.

Although this variant has been found to be more contagious than other SARS-CoV-2 Houston strains, Musser said the good news is the vaccines currently being used in the U.S. are highly effective against the U.K. variant , which will help control the spread and reach herd immunity. The genome sequencing results showed none of the 648 cases had the change in spike protein (E484K) that can cause decreased recognition by antibodies.

Other collaborators working with Musser on this study were Randall J. Olsen, Paul A. Christensen, S. Wesley Long and Sishir Subedi with the Houston Methodist Research Institute and Houston Methodist Hospital Department of Pathology and Genomic Medicine; James J. Davis with the Argonne National Laboratory; and Jimmy Gollihar with the U.S. Army Combat Capabilities Development Command Army Research Laboratory in Austin.

This study was supported by funding from the Houston Methodist Academic Institute Infectious Diseases Research Fund and with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract number 75N93019C00076.